HDX-MS describes different catalytic conformations of an ABC transporter involved in multidrug resistance
The emergence of antibiotic resistant “superbugs” is a real threat for our society and ATP Binding Cassette (ABC) transporters is one of the family of integral membrane proteins that can expel cytotoxic drugs from bacteria, thereby reducing their efficacy. ABC transporters such as BmrA from Bacillus subtilis alternate between two conformations in an ATP-dependent manner:..
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