T lymphocytes are essential cells of the immune system, and have the ability to sense a wide range of antigenic peptides bound to the Major histocompatibility complex (MHC). But they trigger a proper response only after recognition of high-affinity antigens coming from pathogens, while interaction with self-peptides fail to activate them. Through an in-depth, time-resolved..
The spermatoproteasome is found exclusively in mammalian germ cells and is essential for spermatogenesis. It differs from the constitutive proteasome by the presence of only one alternative protein out of the 14 constituting the complex. This work, published on April 4, 2022 in Proc Natl Acad Sci USA, shows that the few amino acids that..
T lymphocytes are essential cells of the immune system, that specifically recognize a wide range of pathogens, but also malignant cancer cells in the body. Upon binding to specific antigens, the T-cell receptor (TCR) triggers a signaling cascade encoded by the rapid and successive phosphorylation of many intracellular proteins. This small chemical modification promotes their..
The emergence of antibiotic resistant “superbugs” is a real threat for our society and ATP Binding Cassette (ABC) transporters is one of the family of integral membrane proteins that can expel cytotoxic drugs from bacteria, thereby reducing their efficacy. ABC transporters such as BmrA from Bacillus subtilis alternate between two conformations in an ATP-dependent manner:..
HDX-MS—based study of the differences between the conformational dynamics of standard and i20s reveals specific, allosteric changes in i20S and upon regulator binding. Nat Commun. 2020 Dec 1;11(1):6140.