Understanding how T lymphocytes discriminate between antigens of varying affinities

T lymphocytes are essential cells of the immune system, and have the ability to sense a wide range of antigenic peptides bound to the Major histocompatibility complex (MHC). But they trigger a proper response only after recognition of high-affinity antigens coming from pathogens, while interaction with self-peptides fail to activate them. Through an in-depth, time-resolved..

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Deciphering the proximal TCR signaling network in mice and humans

T lymphocytes are essential cells of the immune system, that specifically recognize a wide range of pathogens, but also malignant cancer cells in the body. Upon binding to specific antigens, the T-cell receptor (TCR) triggers a signaling cascade encoded by the rapid and successive phosphorylation of many intracellular proteins. This small chemical modification promotes their..

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HDX-MS describes different catalytic conformations of an ABC transporter involved in multidrug resistance

The emergence of antibiotic resistant “superbugs” is a real threat for our society and ATP Binding Cassette (ABC) transporters is one of the family of integral membrane proteins that can expel cytotoxic drugs from bacteria, thereby reducing their efficacy. ABC transporters such as BmrA from Bacillus subtilis alternate between two conformations in an ATP-dependent manner:..

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