Understanding how T lymphocytes discriminate between antigens of varying affinities
T lymphocytes are essential cells of the immune system, and have the ability to sense a wide range of antigenic peptides bound to the Major histocompatibility complex (MHC). But they trigger a proper response only after recognition of high-affinity antigens coming from pathogens, while interaction with self-peptides fail to activate them. Through an in-depth, time-resolved..