Julien Marcoux’s HDR

Structural Mass Spectrometry of membrane proteins and large protein complexes

Building on his expertise acquired around the concept of Structural MS, Julien Marcoux was hired by the CNRS in 2015 at the Institute of Pharmacology and Structural Biology (IPBS, Toulouse) in the Proteotoul team to implement and develop structural MS methods at the IPBS.

Since then, his main research interests include the study of proteins from the (myco)-membrane involved in infectious diseases and multidrug-resistance and the regulation of the proteasome, which has been the main thematic of the team for more than 25 years now.

In the coming years, the group intends to continue working on the description of proteasome subtypes, from a structural and functional point of view, and in the context of inflammation. Similarly, the study of oncoribosomes (funded by the National Institute of Cancer) will benefit from our approach combining shotgun proteomics and structural MS. We also want to go deeper and expand studies of membrane proteins and peptides in the context of antimicrobial resistance, using structural MS methods. More particularly, the group is involved in two funded projects on the study of bacterial metal efflux platforms (collaboration with Olivier Neyrolles) and on pore forming peptides (collaboration with Mike Marty at University of Arizona and Etienne Meunier at IPBS) and another project on the β-barrel assembly machine (BAM) complex (collaboration with Raffaele Ieva at CBI Toulouse).

HDR Committee:

• Prof. Kasper D. RAND, University of Copenhagen, Rapporteur
• D. Yves BOURNE, AFMB Marseille, Rapporteur
• Prof. Isabelle FOURNIER, PRISM, Université de Lille, Rapporteur
• Dr. Odile BURLET-SCHILTZ, IPBS Toulouse, Candidate’s godmother
• Prof. Laurent MAVEYRAUD, IPBS Toulouse, President

 
Julien Marcoux will defend his HDR on october 28.