One of our research areas is to decipher, at the molecular level, the functional mechanisms of T lymphocytes using proteomic approaches.

In collaboration with teams bringing complementary expertise in immunopathology and T cell signaling (B. Malissen, CIML, Marseille; R. Lesourne, CPTP, Toulouse; A. Saoudi, CPTP, Toulouse), we are involved in the detailed characterization of the T Cell Receptor (TCR) pathway, by analyzing the signalosome of several key components of this complex system using AP-MS strategies, or the signaling pathways engaged upon activation of T-cells using phosphoproteomics.