Coordinator: Julien Marcoux

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Structural Mass Spectrometry encompasses an extending range of methods aiming at collecting as much structural information on a biomolecule as possible, including :

  • Native MS and Ion Mobility-MS,
  • Hydrogen-Deuterium Exchange,
  • Top-Down Proteomics,
  • Cross-linking,
  • Mass Photometry.

For a recent review of Structural MS applied to membrane proteins see (Sanchez Dafun and Marcoux, 2022)

Native MS and Ion Mobility-MS

Stoichiometry
Non-cov. binding

HDX-MS

Solvent accessibility
Dynamics / Allosteric change

Top-Down Proteomics

Proteoforms
PTMs, truncations…