Immune cells from the adaptive and innate systems are the players of complex biological processes that allow the elimination of pathogens, but also of malignant cancer cells in the body. In order to develop therapeutic approaches based on the modulation of the immune response, it is important to finely characterize the molecular mechanisms underlying their activation and mode of action.
To that aim, we use state-of-the-art mass spectrometry techniques and proteomic approaches, such as large-scale protein abundance profiling, interactomics or phosphoproteomics, to study the molecular mechanisms of the inflammatory and immune responses in specific cellular systems, such as endothelial cells and different types of immune cells.
